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・ Zinc metalloproteinase STE24
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Zinc pyrithione
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Zinc pyrithione : ウィキペディア英語版
Zinc pyrithione

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Zinc pyrithione is a coordination complex of zinc. It has fungistatic (that is, it inhibits the division of fungal cells) and bacteriostatic (inhibits bacterial cell division) properties and is used in the treatment of seborrhoeic dermatitis.
== Structure of the compound ==
The pyrithione ligands, which are formally monoanions, are chelated to Zn2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer (see figure), where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond.
This compound was first described in the 1930s.
Pyrithione is the conjugate base derived from 2-mercaptopyridine-''N''-oxide (CAS# 1121-31-9), a derivative of pyridine-''N''-oxide.

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